5 ESSENTIAL ELEMENTS FOR METHADONE MAINTENANCE TREATMENT

[61] Like lots of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with distinct potency. Dextromethadone, and that is much less powerful being an opioid, is more potent at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, with an IC50